"Our research shows that the escape of circulating cancer cells from the original tumor is controlled by hormones such as melatonin, which determine our rhythms of day and night"
And you have to think this is somehow related to this research.
Although you would expect the opposite of cancer growing at night, when melatonin is ostensibly at its highest (does it peak or start at 8PM?).
Melatonin is an antioxidant, which destroys chemicals known to cause cancer. I can't find info on it destroying cancer cells directly.
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis
The melatonin immunomodulatory actions in radiotherapy
Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process
Role of melatonin in cancer treatment
Melatonin, a natural programmed cell death inducer in cancer
Cancer metastasis: Mechanisms of inhibition by melatonin
Melatonin and its ubiquitous anticancer effects
Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis
RNA-Seq transcriptome analysis shows anti-tumor actions of melatonin in a breast cancer xenograft model
Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice
Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats
*This is significant because one of the side effects of chemotherapy is increased NFkB, which can induce to tumor growth/resistance*
Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells
Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway
Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells
It really pisses me off when people just keep repeating stuff and never support them with evidence.
This here however -- your tidbit -- is something I can work with and might prompt me to change my habits.
Any idea if taking melatonin pills while still going to bed at 4:00 is having the same, or at least some effect? Or does it not work at all then?
Sleep has been researched heavily (but far from conclusively), and there is an insane amount of diseases that people who don't get enough sleep are a risk group for. And some of those correlations are quite pronounced, like being ~30% more likely to get dementia if you don't get enough sleep in your 50s and 60s.
In some cases nobody can conclusively say whether there's causation, because we don't fully understand diseases like alzheimer or some of the processes happening during sleep, but in the meantime it seems prudent to sleep a healthy amount.
But considering the lifestyle loss from dementia I'd rather risk losing some waking time instead.
So I'm trying to figure out if they're right or not because I'm 42 and I've been a night owl since 12 and yeah, nowadays my health is quite bad and I'm busting my arse trying to fix it.
Your circadian rhythm regulates melatonin release. Not the clock hanging on your wall.
From your other comment, seems like your problem is a very inconsistent sleep pattern and not enough sleep.
Sometimes I sleep 4-5h and then have a huge nap -- 2.5h to 3.5h -- in the early evening. Happens for a week or two. Then I go without naps for a month.
It's relatively cyclical but the periods aren't with fixed values at all. The daily hours are fairly inconsistent as well.
So I must complete heavy workouts every 1-2 days to make my body want to sleep. Maybe start heavy exercise when you feel you're getting near that point.
For me - it is a weight workout (lifting or power lifting). I can do a 1-2 hour cardio workout (or sprints) to get a similar effect.
Guess I'll keep going to doctors like I do lately.
But I did hear from a few trainers and doctors that melatonin can be taken without prescription and is not dangerous, hence my question above.
I'll ask my doctor next time about it.
I would recommend googling rather than speculating in comment threads about unprescribed 'heavy doses' of unregulated supplements.
That's like %99.99 of "scientific" culture. People repeating stuff they heard. Memes.
Society isn't rational. Never was. Never will be.
(Is this post now a self-referential platitude? ...is it self-aware? Maybe I can convince that one Googler it's come to life.)
Looks like a feedback cycle
>> Melatonin exhibited various mechanisms to restrain metastasis, such as modulation of cell–cell and cell–matrix interaction, extracellular matrix remodeling by matrix metalloproteinases, readjustment of the cytoskeleton, epithelial-mesenchymal transition, and angiogenesis . A recent study reported that the overexpression of the ADAMTS family in renal cell carcinoma was suppressed by melatonin via amplifying of miR-let-7f/miR-181d and reducing protein stability. It is of note that ADAMTS, a disintegrin, and metalloprotease with thrombospondin motifs family, thought to have an impact on cell metastasis and developing of cancer stages.
>> Melatonin has short plasma half-life, variable oral absorption, and low variable bioavailability that could be due to extensive first pass metabolism , in addition to its poor solubility and stability . Therefore, conventional oral dosage forms (immediate release) are unsuitable candidates for melatonin delivery.
Running can cause knee issues
They may basically be going out into the blood when there are fewer white blood cells roaming the corridors, looking to kill something.
Just splice the right snippet of elephant DNA into ours to kill cancer for good.
Speaking of sleep, if I was doing the above I'm not sure I'd ever sleep well again.